Chem
415
protein chemistry Fall 2009
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Instructor: |
Office: 222 Scitechl |
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Class Time M 6-9 |
Class room Scietech 362 |
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Email: jfreeman@po-box.esu.edu |
Phone: 570 422 3446 |
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Office Hours: Tues: 9:30-10:30 AM Wed 8:30-11:30AM 1-2 pm Thurs: 9:30-10:30 AM |
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WEB: www.esu.edu/~jfreeman/415 syllabus On web. |
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Text:
Protein Structure and Function : Gregory A Petsko Dangmar
Ringe 2004 New Science Press US
Distrubutar Sinauer Associates ISBN 0-87893-663-7 |
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Goals of Course: |
To Explore the fascinating world of protein science |
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Expected Outcomes of Course: |
Students should be able to |
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understand of the breadth of the field of protein chemistry |
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understand protein-system physical interactions and how structure governs the function of proteins. |
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grasp the three dimensional structure of proteins and
the forces which influence protein folding. know the methods used to determine protein
structures |
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the chemical understand the evolutionary and
genetic origins of proteins. |
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understand
the processes of chemical and biosynthesis of proteins |
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understand the nature of and basic kinetics of enzymatic
catalysis. |
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investigate
scientific literature to explore a topic |
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_To apply the
above knowledge in problem solving |
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Grades will be assigned at the pleasure
ofthe instructor. The following point percentages will result in
the corresponding minimum grades because they presumably
demonstrate
thecorresponding understanding.
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>85% |
A |
Student
demonstrates an ability to understand the course material and to apply
the material to new problems and situations. Student understands the
connections between this course and other science courses and how the
material relates to the world today, |
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>70% |
B |
Student
demonstrates an ability to understand the course material. Student is
able to apply the material to new problems and situations to a limited
extent. |
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>65% |
C |
Student
demonstrates an ability to understand facts relative to course material. |
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>50% |
D |
Student
demonstrates a partial ability to understand facts relative to course
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<50% |
Failing grade |
Unacceptable
Work |
Research Paper:
During the second week of the term you will choose a protein or
class of proteins
towrite
a review paper on. You will focus on structural elucidation primarily
andhow
that might impact function. The paper should cover the evolution of
the structure. The function of the protein is important but of a
secondary
nature in the paper. More details at the time you choose your
protein. Paper coversheet
Academic Integrity:
It is assumed the
all gradedwork
in this class is your own original work. See the student handbook for
thecampus
policy. Violations of the policy will result in penalties up to
andincluding
failing the class. Team work on problem sets and reading of papers
isappropriate and recommended as you will learn more material this
way Please turn in pledge from my home page .
A
Rough
Guide to the progress of the course, the instructor reserves the right
to change
schedule as suits the course.
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Start Date |
Events |
Book readings, Themes and extended
readings |
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1 |
31 Aug |
Chapt 1-0 to 1-1 Topogenisis Lec Blobels Paper |
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2 |
7 Sept |
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1-2
to1-7 forces that goveren Proteins Post tranlational processing Lec Nice link on both topo and post mod and degradation |
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3 |
14 Sept |
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1-8 to 1-13 |
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21Sept |
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1-14 to 1-22 Primary structure
Secondary
structure Forces
that fold |
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5 |
28 Sept |
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Farber
BBarrls |
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6 |
5 Oct |
Week of Exam 1link | Obviously we are behind 1-12 to 1-22 Possibilities of protein structure |
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7 |
12 Oct |
Swich no Tues Class |
Exam Due on 15 oct inclass exam last 50 minutes of class intresting summary of amino acid properties My version write the structrures next to the words |
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a |
19 Oct |
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Binding
lecture 2-11 to 2-14 |
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8 |
26 Oct |
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Allosteric
effects 2-15to 3-4, 3-5 |
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9 |
2 Nov |
Week of Exam 2 |
Exan 1
dissusion Lecture Nov 5 3-1 to3-4 Exam 2 |
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10 |
9 Nov |
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3-5 to 3-9 |
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11 |
16 Nov |
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lLec
Nov 17 3-10 to 3-14Lec
Nov19 |
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12 |
23 Nov |
Thanksgiving |
3-15 |
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13 |
30 Nov |
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3-16 to 3-20 |
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14 |
7
Dec |
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special topics |
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15 |
14 Dec |
Final Exam |
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11 Dec |
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