Laser Scanning Confocal microscopy (LSCM), cryo transmission electron microscopy (cryoTEM), transmission electron microscopy (TEM), small and ultrasmall angle neutron scattering (SANS, USANS), and oscillatory rheology have all been used to characterize the nano-through-microstructure of the self-assembled systems.
![]() The Center
Experience -
Come play with us! What's Alive? - Get a closeup look at life on
earth
Watt's Up? - Experiment with energy and experience the Black Hole tunnel Whats The Matter? - See how matter is made What on Earth? - Explore the earth as an active place and try your hand at weather forcasting What Works? -Forces - can you lift 1,000 lbs? Leonardo's Garden - create your own garden |
The Da Vinci Discovery Center of
Science and Technology -
Please see the Da Vinci center website, www.davinci-center.org for information about the Lehigh Valley's exciting new science center - just opened October 30, 2005 LVACS has reserved the Da Vinci center for our members! Please come out and support your local section - bring your family and have fun! Date: Tuesday, January 24, 2006 Location: Da Vinci Discovery Center of Science and Technology, 3145 Hamilton Blvd Bypass, Allentown, PA Meeting and organization: 5:30-5:45 PM Foyer of the Da Vinci Center Tour of the Da Vinci Center with access to food and beverage stations: 5:45-7:30 PM Poster Session: 7:30-8:30 PM Cedar Crest College Science center - see CCC student research and chat with the students Menu: To be announced - check back soon! Cost: $25.00 adults; $12.50 retirees, children and students; ACS student affiliates FREE! Cash bar available. (applications to become a student affiliate will be available at the meeting. Any student joining the Student Affiliate will receive free admission!) Contact: Tara Baney tara_baney@merck.com 215-652-7486 by Wed. Jan 18 Directions: http://www.davinci-center.org/directions.html |
Date: Thursday
September 22, 2005
Location: Lafayette College
Reception: 5:30 PM Marlo Room -
Farinon Center
Dinner: 6:00 PM Marlo Room
- Farinon Center
Meeting: At conclusion of dinner,
103 Hugel Science Center
Talk: ~ 7:30 103 Hugel Science
Center
Menu: Tossed green salad, rolls,
choice of fresh Atlantic salmon seared with orange fennel beurre blanc
sauce, grilled flank steak with whiskey barbecue sauce or roasted
vegetable
polenta; twice baked potato and green beans. Dessert: peanut
butter
pie
Cost: $22.50 members $12.00 students
Contact: Debbie Bastinelli at 610-330-5213 or
bastined@lafayette.edu
by Sept 15, 2005. Please include name affiliation and choice of
entree.
Directions: Directions can be found
on the web at http://www.lafayette.edu/community/directions.html
Speaker: Dr Hans Schelvis of New York University
Talk: DNA repair by photolyase: Better understanding through spectroscopy
LVACS Meeting Dates for 2004-2005
Student Awards Night & Student Research Poster Session
Students are encouraged to attend
Date: Wednesday, April 27, 2005
Location: Moravian
College
North Campus
Dinner:
6:15 pm UBC Room, Haupert Union BuildingDirections:
Directions to Moravian can be found on the web at http://www.moravian.edu/admission/directions.htm.Speaker:
Larry Murrell, Ph.D.
Larry Murrell received a BS in Chemistry from the Colorado School of
Mines, and a Ph.D. in Inorganic Chemistry from the University of
Illinois. This was followed by postdoctoral work in
Organometallic
Chemistry at the University of Wyoming. Larry¹s career has
been
spent as an industrial chemist first at Exxon Research &
Engineering
Co. Corporate Research - Science Laboratories.
Followed
by serving as a Senior Research Chemist for Engelhard
Incorporated.
He is currently working as the Senior Principle Research
Chemist
at ABB Lummus Global, in Bloomfield NJ. During his career he has
been the author of many publications and patents.
Talk: Sols and Mixtures of Sols as a Way to Prepare Unique Materials
Abstract: Gelation
of colloids, or sols, has been employed in the past 15 years in an
intensive
way to make novel catalytic and sorbent materials [1-3]. It is
intriguing
just how little has been done employing mixtures of
commercially
available sol materials [1]. One of the barriers to prepare these
systems is that many sol systems are incompatible due to the pH and the
counter ions that are used to stabilize commercially available
sols.
The one major advantage of preparing materials from mixed sol
precursors
is simply that these materials can often not be made by any other
procedure. The reality is that formation of crystals within a
pre-formed
support is a barrier to form certain size of crystalline
materials
within the void space provided by the support [1]. In this
presentation
the use of well characterized commercial colloidal materials
provides
useful examples where the starting sol, during the gelling
process,
is completely consumed in the formation of the final
primary
particles in the gelled material. In other cases, the starting
sol
size is maintained and becomes the size of the primary particle
that
is the building block of the final dried and 500OC air treated
catalyst
or catalyst support. In the case of mixtures of sols, evidence
will
be presented for where crystallization processes are altered by
having
two sols present in the gelled state. Recent work has shown that
it is possible to manipulate the gelation behavior of single
oxide
and mixed oxide sols by use of acetone-water mixtures. In earlier
work [4], catalysts were prepared using ruthenium chloride in
acetone
by addition to the pore spaces within magnesium oxide. What
was
intriguing about this earlier work is the fact that excellent
catalysts
were also obtained by having as high a water-acetone weight ratio
as 70-30. It was this previous work that stimulated an
investigation
of mixed acetone-water mixed solution preparations where
colloidal
oxides were investigated. To the best of our knowledge this is
the
first time that inorganic oxide slurries and their mixture have
been
formed as meta-stable slurries, and then subsequently gelled by a
number of procedures.
References:
1.Murrell, L.L., Catal. Today 35 (1997) 225
2.Ward, D.A. and Ko, E.I., Langmuir 11 (1995) 369
3.Balahrishnan, K. and Gonzalez, R.D., J. Catal. 19 (1993) 395
4.Tauster, S.J., Murrell, L.L., DeLuca, J.P., J. Catal., 48, 258, 1977
Location:
Bishop McShea Student CenterReception: 5:15
to 6:15 PM cheeses, strawberries, grapes, crackers, non-alcoholic
champagne, and sodas
Dinner:
6:15 PM
Meeting:
7:30 PM Lecture Hall of Priscilla Payne Hurd Science Center
Talk:
Following meeting
Menu:
Buffet featuring salad, baked ham, fish with fresh tomatoes and spinach
garnish, chicken medallions, pasta, rice pilaf, fresh green beans, baby
carrots with cinnamon butter, tiramisu chocolate cheese cake,
strawberry
shortcake, coffee and tea
Cost:
$20.00 members; $10.00 students
Contact:
Mrs. Renee Fair (610) 282-1100, Ext. 1386 or
Renee.Fair@desales.edu
by Tuesday, May 10 at 4:00 PM
Directions:
Directions to DeSales can be found on the web at http://www.desales.edu/
Speaker: Dr. J. David Lawson, Senior Computational Chemist, Vitae Pharmaceuticals
Talk: Better Living Through (Computational) Chemistry
Abstract: Computational chemistry is a relatively new field within the molecular biosciences. Drawing from biology, chemistry, physics, and computer science, computational chemistry uses computers to understand biologically important processes at the atomic level. Two case studies will be presented. The first describes the role of computational chemistry in elucidating how muscles work at a molecular level. The second describes how computational chemistry is revolutionizing the discovery of new human therapeutics in the pharmaceutical industry. Also presented will be an overview of the potential uses for computational chemistry in primary and secondary education.
|
778th
LVACS Meeting:
|
Please
join
us at PBC for the first annual LVACS pub night. Pocono Brewing Company
has more than 70 beers on tap including several house brews. If that
isn’t
enough more than 200 bottled beers are available. For those interested,
PBC will provide a beer sampling. We will have use of the game room
during
our reception and will enjoy dinner and our meeting in the pub loft. A
private bar will be available for your enjoyment during dinner. Dress
is
casual, so dress on down! PBC is an easy drive from the Lehigh Valley.
Check out the PBC webpage athttp://www.poconobrewingcompany.com/
|
Beer Tasting Reception:
6:00 PM including pool, darts, and video/pub games* Dinner: 7:00 PM Meeting and Talk: 8:00 PM Location: Pocono Brewing Company (PBC) Rt. 611, Swiftwater, PA Menu: Traditional Pub appetizers- chicken wings, beer battered onion rings, potato skins, chips and salsa. Buffet style dinner featuring prime rib and penne ala vodka. Sides items include house salad, green beans almondine, and roasted red bliss potatoes. Dessert - choice of lemon supreme cake with lime filling and vanilla whipped cream icing or Kaluha chocolate cake with raspberry filling and mocha frosting . Beverages- unlimited non alcoholic beverages. Open cash bar will be available. Cost:$26.00
for members Note: You must be over 21 to participate in the beer tasting. Proper ID will be required. Contact: Michelle Jones-Wilson, 570-422-3703 or mjwilson@po-box.esu.edu by Wed., March 16. Please indicate name and affiliation. |
|
Carpooling: We will help to organize those who wish to carpool. Please contact the host above or Tara Baney tara_baney@merck.com, 215-652-7486
Directions:
33 North to 80 west. Exit at rt.611 Scotrun. Make a left at the end of
the ramp and travel N on 611 to PBC on the left. Map available at http://www.poconobrewingcompany.com/
Talk:
Automation: From Drugs To Wine and Beer
Speaker: Adam M. Fermier, Ph.D. , J&J Pharmaceutical Research and Development
Adam M. Fermier started working as a carpenter in his early career
and
then worked in a machine shop to earn some money to get him through
school.
He received his bachelor’s degree in chemistry from Delaware Valley
College
in 1993. He earned his Ph.D. in analytical chemistry from the State
University
of New York at Buffalo in 1997, where he specialized in column
technology
and detection in capillary electroseparation techniques. After a
postdoctoral
appointment in 1998 at Johnson & Johnson’s R.W. Johnson
Pharmaceutical
Research Institute, he accepted a position later that year as Senior
Scientist
in the Spectroscopy/Drug Chemistry/New Technologies Group in Drug
Evaluation.
Dr. Fermier quickly established himself as an innovative scientist
seeking
automated solutions to the routine tasks in the development
laboratories,
and was promoted to Principal Scientist in 2001. His work focuses on
laboratory
automation where he pulls the knowledge gained through his carpentry
and
machine shop experiences to facilitate the automation workflows. He has
designed and implemented a degradation robot (JABA), a crystallization
workstation, and a weighing/sample preparation robot. He has shared his
work with the scientific community in 12 written publications, one book
chapter, 51 presentations, two issued patents, and four patents
pending.
Abstract:
Automation is being introduced into every aspect of our lives including
the laboratory. The term automation describes any process that helps
minimize
human interactions. From a laboratory standpoint, a lot of bench top
practices
are being automated to provide unattended pipetting, weighing, stirring
and temperature control. With these basic functions, we have automated
processes in both academic and pharmaceutical labs and even in our home
brewery. Academically, the introduction of automation to students
prepares
them for advanced research in university and industrial labs and a
productive
career in science. Automation of sample preparation methods
traditionally
done by hand in the laboratory is one area of focus. At Muhlenberg
College,
students have been directly involved in the development and
optimization
of new automated sample preparation methods using robotic workstations
including the solid phase extraction of antioxidants in wine prior to
chromatographic
analysis. The automated extraction is more reproducible and has higher
extraction efficiencies than manual methods. In pharmaceutical
laboratories
the practice of converting manual to automated processes is very
similar.
The first step of automation is to understand the manual process, then
answer the question; can the process be automated? Often the answer is
yes; it just takes time and money. Two automation platforms will be
discussed
here. The first system is a crystallization-screening platform for
small
molecules. This system is based on liquid handlers that ultimately mix
hundreds of different solvent conditions within a few hours. The plates
are then incubated and set aside to monitor crystal growth. Once
crystals
are identified, the stability of the compound needs to be determined.
Stability
for pharmaceutical products is typically a 2-year shelf life at room
temperature.
To help predict shelf lives, reactions are set up at elevated
temperatures
in various formulations and rates of degradation monitored. A robotic
system
was built to stress samples in 2 mL auto sampler vials. These vials are
heated or exposed to light then moved to a cold block, simulating the
process
of removing samples from ovens and humidity chambers back to a
refrigerator.
Multiple reactions can be run simultaneously and in 2004, over 25
compounds
were processed. We were able to take advantage of the temperature
control
software built for the degradation robot and use it in our basement
brewery.
Built over the past 5 years, the system is capable of temperature
control
of the brew tanks through a computer interface. Temperatures are logged
into a tab-delimited sheet every 2 minutes, which can be plotted in,
excel.
The process has provided excellent control and some good results. The
talk
will demonstrate the broad impact of automation from academia, industry
and even our home brewery.
Location:
Cedar Crest College, Miller Building, Harmon Hall of Peace
Social
Hour: Wine
Tasting Reception: 5:30 – 6:30 PM
Dinner:
6:30 – 7:30 PM
Menu:
Salad with strawberry vinaigrette dressing, green beans, roasted
potatoes,
carrot cake, and beverage, with choice of entrée:
Grilled chicken with artichoke hearts , Vegetable Napolean, Cost:
$20.00
for members, $10.00 for spouses and students
Note: You must be over 21 to attend the wine tasting reception
and dinner.
Meeting and Talk: 7:45 PM in room 136 of the Science Center
Speaker: Sharon
Gerdes, Technical Support Consultant for Dairy Management
Inc.
Ms. Gerdes answers the “Do it with dairy”TM hotline, writes
articles for various industry publications, and speaks on the latest
trends
in the dairy industry to a variety of groups.
Title:MOOving
and Shaking with Dairy Ingredients
Dairy ingredients are highly functional and
nutritious
additions to the food formulators’ repertoire. Whey, the by-product of
cheesemaking, was once discarded or fed to animals. Currently there are
dozens of highly specialized food ingredients derived from whey. Some
feature
calcium for enrichment, high gelling for structural support, or instant
solubility for low pH beverage systems.
Get the latest scoop on how dairy ingredients stack
up to hot topics such as weight management, GMO free, organic, and food
allergies. Some of the newer dairy ingredients include hydrolyzed whey
protein isolate which is popular with high-performance athletes, bovine
colostrum which provides natural immune factors, and conjugated
linolenic
acid which shows great promise as an anticarcinogen. Research at six
Centers
for Dairy Research has developed technologies for textured and extruded
whey protein ingredients, whey protein films, and other novel
functionalities.
Directions: Available at www.cedarcrest.edu, click on General Information, then Directions to CCC
Contact:
Dianne Molchany by 4:00 PM on Friday, February 4, 2005 at 610-606-4611
ordkmolcha@cedarcrest.edu
Please indicate name, affiliation, and choice of entrée for
yourself
and your spouse (if attending).
Meeting
and Talk:8:00
P.M.
Location:Northampton
Community College, North Campus, Room 130 Alumni Hall
Directions:Available
at www.Northampton.eduClick
“About us;” then choose “maps and directions.”
Contact: Joan
Bender by 4:00 P.M. on Tuesday, January 11 at 610-861-5533 orjbender@northampton.edu.
Please indicate your name, affiliation, and choice of entrée
at the time of your call.
Speaker:Scott
Hanton, Air Products and Chemicals, Inc
Title:
Polymer MALDI: Innovating with Mass Spectrometry
Abstract:Matrix-Assisted
Laser Desorption/Ionization (MALDI) mass spectrometry has become a very
important technique to characterize the chemical structure of
industrial
polymer materials. MALDI methods have been developed to address a broad
variety of different polymer materials containing different
chemistries.
MALDI data can determine the polymer repeat unit, provide information
about
the end groups, measure impurities, additives, and surfactants in
formulations
and calculate average molecular weights. MALDI is a powerful and
relatively
easy tool to use, with a variety of sample preparation methods that can
be applied. The incredible diversity of synthetic polymers generates
a
significant challenge in efficiently developing effective sample
preparation
methods. Understanding the role of the matrix provides the keys in
developing
new sample preparation methods. This presentation will provide an
introduction
to polymers and mass spectrometry, over some of the underlying roles of
the matrix, examine new sample preparation methods, combine MALDI with
chromatography and use post-source decay to gain increased
chemical
structure information.
Menu:
House Salad, Rolls and Butter, Italian Chicken, Carrots, Oven-Roasted
Potatoes
and Strawberry Shortcake.
Cost:
$20.00 Members; $10.00 students and retirees
Should those eligible for a discount pay full price, the difference
will be donated to the LVACS scholarship fund.
Contact: Sue Snyder 610-285-5056, sqs9@psu.edu by Friday, Nov. 12th
Meeting and Talk: 7:30 PM
Speaker: James
Bohning, Visiting Research Scientist and CESAR Fellow Lehigh University
James J. Bohning, Ph.D., is professor of Chemistry Emeritus at Wilkes
University, where he was a faculty member from 1959 to 1990. He
served
there as chemistry department chair from 1970 to 1986 and environmental
science department chair from 1987 to 1990. He was chair of the
American
Chemical Society’s Division of the History of Chemistry in 1986,
received
the Division’s Outstanding Paper Award in 1989, and has presented more
than 35 papers before the Division at national meetings of the
Society.
He was on the advisory committee of the Society’s National Historic
Chemical
Landmarks Program from its inception in 1992 through 2001, and is
currently
a consultant to the committee. He was on the editorial advisory
board
of the centennial history of the Dow Chemical Company, published in
1997.
Beginning in 1985 he developed the oral history program of the Chemical
Heritage Foundation in Philadelphia, and was the Foundation’s Director
of Oral History from 1990 to 1995. From 1995 to 1998 he was a
science
writer for the News Service group of the American Chemical Society in
Washington,
D.C. He is currently a Visiting Research Scientist and CESAR
Fellow
at Lehigh University.
Talk: Life on the other side of the Hudson: The nineteenth-century battle for control of the American Chemical Society of New York
Abstract:
The American Chemical Society (ACS) dates its origins to a meeting held
on April 6, 1876 at New York University. Promises made by its
founder
to make the organization a national society with meetings held at
various
venues around the country were quickly forgotten, and within a decade
the
society was on the brink of extinction. Considered by
contemporaries
to be a local New York organization, the arrogant officers of the ACS
were
not concerned with making the Society an operation that fostered
research,
education and intellectual stimulation like its European
counterparts.
As membership evaporated and Journal submissions declined, the American
Chemical Society of New York blithely continued as a “gentlemen’s club”
that virtually ignored life on the other side of the Hudson, smugly
considering
themselves the center of chemistry in the United States. They
finally
took notice when Harvey W. Wiley and Frank W. Clarke of Washington D.C.
announced the formation of the Continental Chemical Society in
1890.
For a period of several years the two groups were locked in a fierce
battle,
and when the dust settled Wiley was president of the ACS and the
original
ACS of New York was just a local section of a truly national
organization.
Chemists in the Lehigh Valley quickly seized the opportunity to make
their
voices heard, forming the fifth ACS local section in 1893 and only the
second that was not a previously existing chemical organization.
Directions: On the web at http://www.lv.psu.edu/about/directions.html
Albright
College
Date:
Wednesday, October 20, 2004
Time:5:30-social
hour
Dinner:6:30-dinner
Menu:Assorted
Bread Sticks w/ Butter, Pear Salad with Spring Greens, Chicken Marsala*
OR Flounder with Tomato Fennel Sauce* Wild Rice with Pine Nuts , Stir
Fry
Vegetables, Chocolate/Raspberry Mousse Parfait, *Please specify a
choice
of entrée
Cost:$20.00
Meeting and Talk: 8:00
Location:Albright
College, Campus Center South Lounge (social hour and dinner) and
Merner-Pfeiffer
Hall of Science Room 217 (speaker).
Contact: Nancy
Kerper by 4:00 P.M. Wednesday October 13, 2004 (610) 921-7720 ornkerper@alb.edu please
specify a choice of entrée.
Directions:Available athttp://www.albright.edu/about/directions.html
Speaker:Curt
Hare Ph.D.,
Professor Emeritus, University of Miami; Research Professor, Franklin
and Marshall College.
Title:Organics
in Your Water
Abstract:We
are probably all aware of the environmental problems associated with
pesticides
and chlorinated organic molecules. These anthropogenic molecules are
now
in a general decline but remain on the EPA’s priority pollutant list.
The
interest of environmental groups, particularly the Greens of Europe, is
now focused on pharmaceuticals and personal care products (PPCP’s).
Little
attention has been paid until now about the environmental fate of the
caffeine
in your cup of coffee or the ibuprofen for your headache let alone the
female birth control pills, perfumes, antibiotics and other chemical
products.
The molecules that we wash down the sink and flush down the toilet are
now appearing in our streams and may have a future impact on our water
supplies.
Biography:Curt Hare earned his Bachelor of Science degree in chemistry at the Pennsylvania State University and his Doctor of Philosophy at Michigan State University. Between tours of academics he served in Korea as a lieutenant in the Signal Corps of the 24th Infantry Division. Upon completion of his doctorate Dr. Hare accepted a National Science Foundation post-doctoral fellowship at the Institute for Physical Chemistry, University of Copenhagen. After this research in Denmark, he accepted an assistant professorship at the State University of New York, Buffalo. Quickly trading snow for sand, Dr. Hare moved to the University of Miami where he was associate chair of the department for several years. He is currently anemeritusprofessor. For ten years, Dr. Hare was the vice president of TransChemical Corporation, and he was also a past president of the Manatee Sulfur Company. Curt has received numerous awards including Professor of the Year (several times), Provost Excellence in Teaching Award, and the Freshman Teaching Award.
Dr.
Hare is an active member of the American Chemical Society, serving as
section
chair and local chair. He has been active in research and is author or
coauthor of 23 peer reviewed publications and two book chapters on
spectroscopy
and its applications to chemistry. His research and industrial
interests
include water pollution, air pollution, cancer chemotherapeutics,
mineral
resources, chemical marketing, chemical industry economics, industrial
chemical training, and recycling of waste plastic by conversion to
fuel.
He has been energetic in the area of chemical education including: 1)
an
interdisciplinary science program (Project SUCCEED) designed to enhance
the abilities of middle school teachers and students funded by the
Department
of Education and the National Science Foundation and 2) a cooperative
program
for minority students between the University of Miami and Miami-Dade
Community College sponsored by the Howard Hughes Medical Institute and
the National Institutes of Health.
LVACS
and Philadelphia ACS Joint Meeting
Date: Thursday, September 30, 2004
Location:Merck & Co., Inc. West Point, PA,
Social hour:5:00
Dinner: 6:00 Oasis Dining Area in Building 53 Cafeteria
Menu:Buffet style – stations are as follows:
Hors d'oeuvre station: Fruit & Cheese – Fresh sliced fruit and gourmet domestic and imported cheese displayed with an assortment of crackers and dipping sauces
Dinner stations:Caesar Salad Bar – Crisp Romaine lettuce presented with Parmesan cheese, garlic croutons and zesty Caesar dressing Pasta Bar – A variety of pastas served with Parmesan cream or marinara sauce. Fresh steamed seasonal vegetables and your choice of shrimp or chicken Coffee, Water, & Sweets – Freshly brewed coffee served with a variety of miniature pastries. No alcoholic beverages allowed on site.
Cost:$20.00 Members; $10.00 students and retirees Should those eligible for a discount pay full price, the difference will be donated to the LVACS scholarship fund.
Contact:Libby
Harper, Philadelphia Section ACS office, (215) 382-1589; PhilaACS@aol.comby
22-Sept-2004.
Meeting
and Talk:Building
37 Auditorium (no food or beverage allowed in auditorium)
Speaker:Dr. Robert P. Bates , University of Florida
Talk:What You Always Wanted To Know about Chemicals in Foods but Were Afraid To Eat
Abstract:Foods are complex mixtures of chemicals, but with difference. There is a very important legal distinction between naturally occurring food constituents and other chemicals that end up in food by design or default. Conversely, the much more important matter, chemical
compatibility, dictated by human physiology and nutritional biochemistry and vital to well-being, health, performance, and survival -- is often ignored or misinterpreted by vocal yet chemically illiterate groups. Despite considerable progress in understanding the science and technology of foods, culture and perception have a far greater influence upon food acceptance and regulation than the reality of nutrition and toxicology. Paradoxically, as science uncovers more about the
complex
interactions of foods with the human body, the less confident and more
confused the public becomes regarding the safety, value, and
nutritional
efficacy of the U.S. food supply. Food additives and now phytochemicals
are examples of food consumption concerns that should also stress total
diet, lifestyle, and common sense. This presentation will deal with
both
essential and trivial food constituents and emphasize some of the
positive
and negative aspects of each. Despite our imperfect and changing
knowledge,
a better appreciation of the chemistry and metabolism of foods has
dramatic
potential for improving health and well-being, while ignorance is sure
to have the opposite effect.
Directions:
From The PA Turnpike (East or West):
Take PA Turnpike to Exit 339 (Fort Washington) to Route 309 North. Exit Route 309 at Norristown Road/Springhouse. Turn left at the end of the ramp onto
Norristown Road. This becomes Sumneytown Pike. Cross over Route 202. (The William Penn Inn is on this corner.) Continue through Gwynned and North Wales (Sumneytown Pike is called Main Street in North Wales). Go under a railroad overpass. At the next traffic light, make left into the Merck facility, Building 53B Entrance, Merck Gate 1. Proceed towards Visitor’s Lot, enter at Main Entrance, and proceed to Security Personnel.
From the PA Turnpike Northeast Extension (Route 476):
Take the Northeast Extension of the PA Turnpike to Exit 31 (Lansdale). Turn left at end of ramp onto Sumneytown Pike. Travel east on Sumneytown Pike through 5 traffic lights. At Octagon Vol. 87, No. 6 pg 2 the sixth traffic light, make a right into the Merck facility, Building 53B Entrance, Merck Gate 1. Proceed towards Visitor’s Lot, enter at Main Entrance, and proceed to Security Personnel.
From Route 202:
Take Route 202 to Sumneytown Pike West. (William Penn Inn is at the corner of this intersection) Travel west on Sumneytown Pike through 4 traffic lights. (Sumneytown Pike is called Main Street in North Wales.) Go under railroad overpass. At the next traffic light, make a left into the Merck facility, Building 53B Entrance, Merck Gate 1. Proceed towards Visitor’s Lot, enter at Main Entrance, and proceed to Security Personnel.
From New York - New Jersey:
March - Cedar
Crest College -
The LVACS,
Cedar
Crest College, and Air Products and Chemicals, Inc. are proud to
present: Spouses
Night/Winery Tour
Date:
Thursday, March 18
Location:
Blue Mountain Vineyards and Cellars, 7627 Grape Vine Drive, New
Tripoli, PA 610-298-3068
Time:
6-9 p.m.
Event: Join
hosts Vickie and Joe Greff, owners of the Blue Mountain Vineyards and
Cellars for hors' deouvres and a buffet supper, a tour of the winery
and the process of winemaking, and a sampling of wines produced at Blue
Mountain Vineyards and Cellars.
Menu:
Hors' Deouvres include a cheese tray with assorted crackers and
mustards, and a fresh fruit tray. A vegetarian pasta buffet
dinner will include: Penne Pasta Primavera, Cheese Tortellini,
Eggplant Parmesan, many different sauces, Mixed Greens with House
Vinaigrette, Garlic Bread, and Brownies for Dessert. In addition
to the fine wines served, there will be non-alcoholic beverages as well.
Cost:
$22.00, $11.00 for spouses of members, students and retirees.
Should those eligible for a discount pay full price, the difference
will be donated to the LVACS scholarship fund.
(Note that all persons must be 21 or over to attend this event, valid
ID will be required)
Contact:
Please contact Diane Molchany, Science Secretary at Cedar Crest
College, (610)-606-4611, or by email: dkmolcha@cedarcrest.edu.
Deadline for
reservations: Thursday, March 11 4:00 p.m
Directions
to the Blue Mountain Winery can be found on the web at http://www.bluemountainwine.com/directions/index.html.
Date: Wednesday,
February 18 - Kutztown University
Reception: 5:15 Viewpoints Dining Room in
the South Dining Hall on the South Campus of Kutztown University
Dinner: 6:00 Viewpoints
Dining Room in the South Dining Hall on the South Campus of Kutztown
University
Meeting: 7:15
Talk:
Cost: $13.25
Menu: Chicken Marsala
including rice pilaf, hot vegetable, salad, rolls, coffee and tea, and
dessert.
Contact: TBA
Talk: A Chemical Odyssey
Abstract: A retrospective of my research experience in academe, this talk will address some of the issues that have been germane to my professional career: women in chemistry, undergraduate research, physical organic chemistry. Although the details of this presentation are necessarily unique to my own work, I will also attempt to state some general principles common to academic research.
Directions: campus map
From the West
Date: Tuesday January 27, Albright College
Reception:
Dinner:
Meeting: 7:45 Merner-Pfeiffer
Hall of Science
Room 217
Talk:
Cost:
$20.00
Menu: Assorted Bread
Sticks w/ Butter, Pear Salad with Spring Greens,Chicken
Contact: Nancy
Kerper by
Speaker: Curt Hare Ph.D.,
Professor Emeritus,
Curt Hare
earned his Bachelor of Science degree in chemistry at the
Dr. Hare is an active member of the American Chemical Society, serving as section chair and local chair. He has been active in research and is author or coauthor of 23 peer reviewed publications and two book chapters on spectroscopy and its applications to chemistry. His research and industrial interests include water pollution, air pollution, cancer chemotherapeutics, mineral resources, chemical marketing, chemical industry economics, industrial chemical training, and recycling of waste plastic by conversion to fuel. He has been energetic in the area of chemical education including: 1) an interdisciplinary science program (Project SUCCEED) designed to enhance the abilities of middle school teachers and students funded by the Department of Education and the National Science Foundation and 2) a cooperative program for minority students between the University of Miami and Miami-Dade Community College sponsored by the Howard Hughes Medical Institute and the National Institutes of Health.
Title: Organics in Your Water
We are
probably all aware of the environmental problems associated with
pesticides and
chlorinated organic molecules. These anthropogenic molecules are now in
a
general decline but remain on the EPA’s priority pollutant list. The
interest
of environmental groups, particularly the Greens of Europe, is now
focused on
pharmaceuticals and personal care products (PPCP’s). Little attention
has been
paid until now about the environmental fate of the caffeine in your cup
of
coffee or the ibuprofen for your headache let alone the female birth
control
pills, perfumes, antibiotics and other chemical products. The molecules
that we
wash down the sink and flush down the toilet are now appearing in our
streams
and may have a future impact on our water supplies.
Reception: 5:45 PM
P&J's
Cafe Atrium (Center for Hospitality Management)
Dinner: 6:15 PM P&J's
Cafe
(Center for Hospitality Management)
Meeting: 7:15 PM
in Moore
Biology Kurz Lecture Hall
Talk:
7:30 PM
in Moore
Biology Kurz Lecture Hall
Cost:
$22, Students $11
Menu: Greek
Been Soup, Broccoli Salad
Entree - Chicken Kiev (skinless chicken breast
with chives, garlic, parsley baked to a golden brown) OR Ratatouille
Provencal (classic vegtable stew with eggplant, onion, tomato, flavored
with fresh herbs and spices). Each served with Italian Zucchini,
sliced, sauteed in olive oil, braised in freshly made stock and Pesto
Potatoes Parmesan, small new potatoes mixed with Parmesan and Romano
cheese in a fresh pesto sauce.
Desert -Choice of flavored scones, oatmeal
date bars with chocolate icing or fruit cobbler
Meeting: 7:30
in Moore Biology Kurtz Lecture Hall
Contact: Kathy Curnoles
(kcurnoles@esu.edu
or 570-422-3514) by Thursday Nov. 13, 4:00 PM. Please include your
name,
affiliation and phone number, choice of entree and desert.
Speaker: Dr. John Elwood, East Stroudsburg University
John received his Ph.D. in Physics from the
California Institute of Technology and a B.A. in both Physics and
Chemistry from Cornell University. John was an assistant
professor at Kent State and from there came to east Stroudsburg
University. His research interests involve the study of quark and
lepton hierarchies with an emphasis on their implications for
unification and the nuetrino sector. He also has an avid interest
in String Theory, M-Theory and physics beyond the standard model.
Title:
Now We See the Past, Darkly
Dark Matter. Dark
Energy. When did the universe get so dark? In this journey
to the frontier of cosmology, we'll explore the dynamics of the
universe and, in particular, touch on the implications that recent
observations have for its mysterious "dark" components. The roles
of particle theories, string theories and brane theories in
illuminating cosmic structure will also be discussed.
Joe Vinson was born in Arkansas and grew up in the San Francisco Bay area. He attended college at the University of California at Berkeley, where he received his B.S. in chemistry in 1963. He received a M.S. degree (in physical organic chemistry) at Iowa State University in 1966. He received a research assistantship at the Ames Lab of the Atomic Energy Commission at Iowa State and received a Ph.D. in organic and analytical chemistry in 1967 under the direction of Dr. James Fritz. After several teaching positions in Pennsylvania and a two-year stint in industry at J. T. Baker Chemical Company, he returned to academe and is now a professor of chemistry at the University of Scranton. His research interests are wide-ranging and include drug analysis in physiological fluids and the effect of vitamins, minerals, and antioxidants on nutrition and health.
Abstract: Food and beverages derived from cocoa beans have been consumed by humans for 1500 years, and the beverage was originally used as currency and in religious rites by the Mayans and Aztecs. A short history of chocolate will give some perspective to the science of chocolate. Cocoa pods from the cacao tree Theobroma cacao are harvested and the beans removed from the pods and fermented. Dried and roasted beans contain about 300 chemicals including unique fats, alkaloids, and simple and complex polyphenols. The manufacturing process results in the production of the various types of chocolate including white chocolate, milk chocolate, dark chocolate, and cocoa powder. Chocolate is purported to have aphrodisiac properties and one ingredient acts on the cannabinoid (marijuana) receptor. Chocolate's antioxidant properties will be outlined and compared with other foods. How chocolate's fat and antioxidants are related to heart disease will be discussed in terms of epidemiological, animal, human supplementation, and mechanistic studies. Recent animal and human studies will be described to determine whether chocolate should be considered a guilt-free food.Speaker:
Dr. Neil Marsh
Neil Marsh received his Bachelor’s degree in Chemistry from the
University
of Cambridge, and his Ph.D. in Biochemistry, also from Cambridge.
He spent time as a Postdoctoral fellow in the Chemistry Department at
Johns
Hopkins University, Baltimore, and was subsequently awarded a Research
Fellowship from the Royal Society that he held in the Biochemistry
Department,
University of Cambridge. Since 1995 he has been on the faculty of
the Chemistry Department at the University of Michigan where he is
currently
Associate Professor of Chemistry.
Talk: “The good news about free radicals: how, and why, enzymes make radicals”
Abstract: Our major interest is in enzymes that use free radicals (a carbon with an unpaired electron) to catalyze a variety of unusual reactions, many of which have no ready counterpart in organic chemistry. Normally, organic radicals are thought of as highly reactive species that are dangerous to biological systems. However, enzymes can profoundly alter the reactivity of free radicals so that a radical with a lifetime of microseconds in free solution may be stable for days when generated within a protein! Enzymes are therefore able to exploit free radicals as “sparks” with which to ignite reactions on otherwise un-reactive substrate molecules.
We are studying a class of enzymes that use the cobalt-containing organo-metallic coenzyme B12 to generate free radicals. These enzymes provide excellent model systems with which to study free radical catalysis. We are using a variety of kinetic and spectroscopic techniques, together with site-specific mutagenesis to understand how the enzymes generate and control reactive organic radical species.
Speaker: Dr. Lawrence
Quarino
Dr. Quarino received a B.S. in Biology with a Chemistry minor (1983)
from Saint Peter's College in NJ, an M.S. in Forensic Science (1987)
from
John Jay College of Criminal Justice in NY, and a Ph.D. in Criminal
Justice
with a Forensic Science concentration (2000) from City University
of New York. Dr. Quarino is a Fellow of the American Academy of
Forensic
Scientists and is certified by the American Board of
Criminalistics.
From 1990 through 2001, Dr. Quarino worked as a Forensics Scientist in
the Office of the Chief Medical Examiner, City of New York, where he
supervised
the operation of the forensic biology laboratory, conducted method
validation
and research on forensic analysis, and provided expert testimony in
criminal
court proceedings. Currently, he is the Director of the Forensic
Science Program and is an Assistant Professor of Forensic Chemistry at
Cedar Crest College.
Talk: Could Horatio Caine and Catherine Willows Function In a Real Forensic Laboratory?
Abstract: The inaccuracies of television portrayals in the professional life of the forensic scientist will be discussed. Of daily concern to the average forensic scientist are issues related to evidence admissibility, quality assurance, accreditation, and training. These topics play little or no role in the professional lives of "television" forensic scientists but are the bedrock for sound scientific criminal investigation. Discussion will focus on how these topics would affect the simulated forensic work performed on television shows. The distortions of the role of the forensic scientist in the criminal justice system and will also be exposed.
Date: Tuesday, April 15, 2003
Location: Moravian College
North Campus
Reception and Undergraduate Student Research
Poster Session: 5:00 6:15 pm, Lobby Collier Hall of
Science
Dinner: 6:15 pm Saal, Bahnson
Center, Moravian Theological Seminary
Meeting: 7:30 pm Dana Lecture
Hall, Collier Hall of Science
Talk: At the conclusion of the
meeting - 7:30 pm Dana Lecture Hall, Collier Hall of Science
Menu: Choice of Boneless Breast
of Chicken Almond Crusted w/Pineapple Orange Sauce, Flounder
Florentine,
or Pasta Primavera
Cost: $20, students $10
Contact: LouAnn Vlahovic by Noon,
Thursday, April 10th. Please include your name, affiliation, and choice
of dinner entree.
Registration can be made by phone (610-861-1300) or by email: melnv01@moravian.edu
(the last two digits are numbers).
Directions: Directions to Moravian can be found on the web at http://www.moravian.edu/admission/directions.htm. Note that due to campus construction, Main Street is closed between Laurel and Elizabeth Avenues. Suggested parking is in Lots M, N, & O, along Locust Street, which can be accessed from New Street. New street is one block east of Main Street. A campus map is available at http://www.moravian.edu/campusMaps/north.htm.
Speaker: Ms. Valerie Kuck
Valerie Kuck received a BA in Chemistry from Saint-Mary of the Woods
College in Indiana and a MS from Purdue University. In 2001
she retired from Bell Laboratories in Murray Hill, NJ, where she had
worked
for 34 years. Her research was in both fundamental and applied areas
and
has been granted 21 U.S. patents dealing mostly with coatings and
waveguide
devices. Currently, she is an adjunct professor in the Women¹s
Study
Program at Seton Hall University, South Orange, NJ. In
collaboration
with other faculty members, she has been conducting research on the
progress
women are making in
academe. In 1997, Ms. Kuck became a Career Consultant for the
ACS and has assisted numerous members in rewriting their resumes. In
1999
she established the North Jersey Section¹s Careers in Transition
Group.
She chairs the Group¹s monthly meetings which address topics such
as resumes, job searching and interviews.
Talk: Writing a Winning Resume for a Tight Job Market
Abstract: The current economy requires job seekers to have attractive, concise resumes that clearly highlight valued skills and noteworthy accomplishments. To assist both experienced chemists and students, pointers and suggestions in preparing effective resumes will be presented. In addition, a resume template that many have found helpful will be discussed.
Speaker: Catherine M.
Bentzley,
Ph.D.
Dr. Bently received her B.S. degree from St. Joseph's University in
Philadelphia, and followed with a Ph.D. from the University of
Delaware.
Her thesis work on analysis of oligonucleotide strands and their
reactivities
by Matrix-Assisted Laser Desorption Ionization was advised by Murray V.
Johnston. She is currently an Assistant Professor at the
University
of the Sciences in Philadelphia where she supervise an active
research
group of graduate and undergraduate students. Her research
interests
include the analysis of protein-kinase catalyzed reactions using ESI-MS
Conformation changes in oligonucleotide strands using ESI-MS,
degradation
of oligonucleotide products during freezing/thawing and ALDI-TOF
Analysis
of Amiodarone in Human Heart Tissue
Talk: "Investigations of the Decomposition, Fermentation and Conformation of Biological Systems using Mass Spectrometry "
Abstract: The rapid and enormous
expansion in the biotechnology revolution has caused increased interest
in determining exact molecular weights of biological systems. Mass
spectrometry
offers a quick and convenient method for determining accurate molecular
weights of biological samples including peptides, proteins,
oligonucleotide
and oligosaccharides. Matrix-Assisted Laser Desorption Ionization and
Electrospray
Ionization are the two predominant mass spectrometry techniques
used
for the development of biological assays.
During the MALDI process singly-charged analyte
ions are produced after desorption/ionization from a matrix using a
nitrogen
laser. For example, in our laboratory we utilize MALDI to track the
fermentation
process of drug products. In another study MALDI is used to track the
decomposition
of PCR primers over various periods of time ranging from 1 day to 10
years.
In contrast to MALDI, the ESI method ionizes an analyte to form charged
species through desolvation of microscopic droplets. A resultant ESI
spectrum
contains a multiply protonated envelope of various mass-to-charge
ratios.
ESI can also be utilized to study the conformational changes of protein
structures as they undergo desolvation. It is also possible to analyze
the denaturing of oligonucleotide strands as the sample enters the
gaseous
phase.
February 20, Lafayette College
Reception: 5:30 pm -
Faculty
Dining Room - Maquis Hall
Dinner: 6:00 pm - Faculty
Dining Room - Marquis Hall
Meeting: 7:30 pm - Gagnon
Hall - Hugel Science Center
Talk: At
conclusion of meeting
Cost: $20, students
$10
Menu: Slow Roasted Prime
Rib of Beef, Hazelnut Crusted Salmon, or Eggplant Roulade Twice baked
potato
Chef's choice vegetable Peanut butter pie
Contact: Debbie Bastinelli
by noon on Friday February 14th. Please provide name,
affiliation,
choice of entree and contact information. e-mail -
bastined@lafayette.edu
; phone - (610) 330-5213
Speaker: Paul Bouis, Ph.D.
Title of Talk: The Legacy of a Zinc City
The Speaker: Paul Bouis was born in Nice, France and immigrated to the United States when he was six years old. The son of a Chemist/Perfeumer he was destined to a life in chemistry. Currently Paul is Director of Research and Technology for laboratory Products at Mallinckrodt Baker. Paul holds a BS in chemistry from the Virginia Military Institute and a PhD in Physical Organic Chemistry from the University of Tennessee. Paul has authored chapters on radioactivity, chromatography and other analytical chemistry techniques. He is chair of the Reagent Chemicals Committee for the American Chemical Society. He is once again serving as chair of the Lehigh Valley section of the ACS. He has periodically been an Adjunct Professor teaching various aspects of analytical chemistry. His research interest is in the area of purification of biopharmaceuticals and organic solvents.
Abstract:
Before Bethlehem Steel began its downward spiral
into Chapter 11 bankruptcy another Lehigh Valley industrial giant had
disappeared
from the ranks of the valley’s great companies. New Jersey Zinc,
which settled in Palmerton, did so for many of the same reasons that
Bethlehem
Steel settled in Bethlehem. It disappeared for many of the same
reasons
Bethlehem Steel soon will.
In this talk we will reminisce about the birth, life and death of a company and an industry, which left a permanent mark on the city, citizens, and landscape of Palmerton. We will examine the chemistry involved in zinc processing and the role it played in the eventual demise of New Jersey Zinc.
So that we do not forget the part this company
played in improving the way of life for all mankind we will review the
many contributions zinc and its compounds have made to modern society.
Directions:
Marquis Hall is building number 21 on the campus map. Parking may
be found near the area marked March Field, or on the Parking Deck
(2).
Hugel Science Center is building 6 on the campus
map.
http://www.lafayette.edu/community/campusmap/campmap.htm
Reception: 5:30pm, Hoffman
House,
N 23rd Street
Dinner: 6:00pm, Hoffman
House,
N 23rd Street
Business meeting:7:15pm
Trumbower
130 lecture hall
Talk: 7:30pm Trumbower
130 lecture hall
Price: $20.00 , students
$10
Menu: Chicken breast stuffed with
Feta cheese, spinach and pine nuts, or Balsamic Flank steak, or
Vegatarian.
Reservations: please call LuAnn Feist at 484-664-3260 or email
feist@muhlenberg.edu
by noon Jan 17th. Please give you name, affiliation, choice of
entrée
and phone number
Title of Talk: “Important Biochemical Advances in the Understanding of Cancer: the interaction of S100B with the tumor suppressor protein p53.”
The Speaker: David J. Weber earned his B.S. in Chemistry at Muhlenberg College and his Ph.D. at the University of North Carolina. He was a Post Doctoral Fellow at The Johns Hopkins University School of Medicine. Currently he is an Associate Professor in the department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine in Baltimore MD. The general focus of his research is to study how metal ions (such as calcium) regulate important proteins and enzymes in the brain.
Abstract: One project in our laboratory involves studies of the structure and function of S100B, a glial-derived protein from the brain. S100B is a dimeric Ca2+-binding protein that is overproduced during gliosis in patients with Alzheimer disease, Down syndrome, and Aids related dementia. In addition, S100B and/or other members of the S100 protein family (S100a, S100L, etc.) are found at high concentrations in several tumor cell lines including lung, bladder, kidney, cervix, breast, head and neck, larynx, lymph, and mouth. Thus, overproduction of S100 proteins may cause problems in the regulation of cell growth in these diseases. Presumably, the function of S100B is related to its ability to bind a variety of target proteins in a Ca2+-dependent manner. One such target is the tumor suppressor protein, p53. For this protein, we have shown that upregulation of S100B abrogates p53 transcription activation in tumor cell lines and that S100B binds and inhibits both the protein kinase C-dependent phosphorylation and the oligomerization of p53 in vitro. Therefore, the focus of our laboratory is to determine, at atomic resolution, the mechanism by which S100B can affect p53 transcription activation and promote uncontrolled cell growth. In this regard, we have determined the three-dimensional structure of apo-S100B, S100B-Ca2+, a S100B-Ca2+-p53 peptide complex using NMR spectroscopy. The structural studies of S100B are imperative for the efficient design of biochemistry and molecular biology experiments that are also completed in our laboratory. Knowledge about the structure and function of S100B is also used to design molecules that inhibit S100B from binding to p53. Perhaps one of these molecules will be practical as a drug for regulating uncontrolled cell growth in vivo. Similarly, structure/function studies are underway for two other members of the S100 protein family, S100a and S100L as well as for other proteins that bind the C-terminus of p53 including a hepatitis B viral protein (HBP) and the high mobility group protein-1.
Directions
to Muhlenberg College
Campus Map
Tuesday, November 19, Lehigh University
Reception: 5:15 Asa Packer
Dining
Room, University Center #29
Dinner:6:15 Asa Packer Dining Room,
University Center #29
Meeting: 7:30 Neville 1
Talk: , 7:45 Nelville 1
Cost: $20, students $10.
Menu: Choice
of Lime Marinated Flank
Steak
with Chipolte Honey Sauce, Sauteed Chicken Breast Tossed with Tomatoes,
Mushrooms, Shallots or Chef’s Vegetarian (available on
request).
Each entree served with salad, vegetable, pasta, rolls, and dessert.
Contact: Dinner reservations
deadline
is 5:00 PM Wednesday, November 13. Respond to Connie Bovee
clb7@lehigh.edu
(note: the second character in the email address is the letter "el") or
(610)758-3471 and indicate for each person who will attend {name,
affiliation,
phone number, and entrée choice}.
Speaker: Peter
C. Jurs, Ph.D.
Chemistry Department, 152 Davey Laboratory, Penn
State University, University Park, PA 16802
Peter C. Jurs is Professor of Chemistry at The Pennsylvania State University. Jurs received his B.S. in chemistry from Stanford University his Ph.D. in chemistry from the University of Washington. He then joined the faculty of Penn State University, where he has been Pro-fessor of Chemistry since 1978. Jurs has been a member of the American Chemical Society since 1965 and has served as an elected Councilor for the Computer Division for twenty years. He has served on a number of editorial advisory boards (Analytica Chimica Acta, Analytical Chemistry, Journal of Chemical Information and Computer Sciences, Chem-Tech and Journal of Medicinal Chemistry). He was awarded the A.C.S. Award for Com-puters in Chemistry in 1990. He has published approximately 250 papers, books, and chap-ters. Jurs's research interests include the application of computer methods to chemical and biological problems. He has been actively involved in research in (a) structure-property rela-tionship studies including prediction of physical and chemical properties; (b) structure-activity relationship studies of biologically active compounds such as pharmaceuticals and genotoxic compounds (e.g., human intestinal absorption, drug potency, acute toxicity, ge-netic toxicity). Jurs's teaching responsibilities at Penn State have included courses ranging from Introductory Chemistry through advanced undergraduate courses to graduate courses in analytical chemistry. He has been heavily involved in recent reforms of Penn State’s In-troductory Chemistry courses. He is a co-author of a recently published introductory chem-istry textbook Chemistry: The Molecular Science.
Talk Title: Prediction of Chemical and Biological Properties of Organic Compounds from Molecular Structure
Abstract: Relationships between the molecular structures of organic compounds and their chemical or biological properties can be investigated using quantitative structure-activity relation-ship (QSAR) methods. This approach uses induction to seek generalities by examining large sets of training set compounds. Such QSAR studies involve three major activities: representation, feature selection, and mapping. Representation involves calculating mo-lecular structure descriptors to encode the compounds. General classes of descriptors in-clude topological, geometrical, electronic, and polar surface area representations of the molecules. Topological descriptors are calculated directly from the connection table repre-sentation of the structure and employ methods drawn from mathematical graph theory. Geometric descriptors are calculated from three-dimensional molecular models which are generated with molecular orbital methods. Electronic descriptors come from empirical or molecular orbital calculations. Polar surface area descriptors are calculated using several of these representations and are meant to encode the potential for polar interactions. In-termediate between representation and mapping is feature selection, which involves select-ing the most informative subsets of descriptors from the descriptor pool using statistical methods, simulated annealing, or the genetic algorithm. Mapping involves building mathematical models linking the descriptors directly to the chemical or biological property under investigation. Statistical regression and computational neural network methods are used. After their development from a training set, these models then can be used for pre-dicting the activity of interest for unknown compounds. The capabilities described here have been incorporated into an interactive, user-driven software system called ADAPT.
Recent investigations involving computational neural networks and genetic algorithms will be described as examples of the application of the QSAR methods. Three-layer, feed-forward neural networks trained with a quasi-Newton method have provided excellent re-sults in several QSAR studies. The genetic algorithm has been shown to be very effective in performing descriptor selection. Several specific, recent QSAR studies will be dis-cussed, including studies of prediction of the aqueous solubilities of organic compounds, the prediction of Tetrahymena toxicity, and prediction of chromosomal aberration poten-tial.
Directions to Lehigh University with campus map
October 15, Kutztown University (Please note this is a change from the previous date of October 17!!!!)
Reception: 5:30 PM South
Dining
Hall, Viewpoints Dining Room
Dinner: 6:30 PM South Dining
Hall, Viewpoints Dining Room
Meeting, Talk: At
conclusion of dinner, South Dining
Hall, Viewpoints Dining Room
Cost: $20.00 for
members,
$10.00 for students.
Menu: Salad, Moroccan
chicken,
rice pilaf, vegetable medley, Strawberry cheesecake.
Contact: Please contact Donna
Moore,
Dept Physical Science Secretary (610) 683-4447. Please provide
name
and affiliation. The deadline for reservations is Oct. 9 at 4:00
pm.
Speaker: Dr. Jeff Saven
Born in Manhattan, KS, Dr. Jeffrey G. Saven obtained his B.A.
degree in Chemistry from New College of the University of South Florida
in 1988. As an NSF Graduate Fellow, he earned his Ph.D. degree in
Chemical Physics from Columbia University. However, the bulk of
his
dissertation research was done while working with Dr. James L. Skinner
in the Department of Chemistry at the University of Wisconsin, Madison,
where he studied applications of statistical mechanics and simulation
to
condensed phase spectroscopy. He was an NSF Postdoctoral Fellow
at
the University of Illinois, Urbana-Champaign, where he studied protein
folding with Dr. Peter G Wolynes. Dr. Saven has been an assistant
Professor in the Department of Chemistry at the University of
Pennsylvania
since 1997. His honors include a Research Innovation Award and an
NSF CAREER Award. He is also a Cottrell Scholar and an Arnold and
Mabel Beckman Young Investigator. His research interests include
the theory and simulation of molecular folding and combinatorial
design.
For a recent review of his current work please see:
J. G. Saven, Designing protein energy landscapes. Chemical Reviews,
2001. 101(10): p. 3113-3130.
J. G. Saven, Combinatorial protein design. Current Opinion in
Structural Biology, 2002. 12: p. 453-458.
Talk Title: Combinatorial
protein
libraries: approximate approaches to protein design
Understanding
molecular
folding has important applications to interpreting genetic information,
to understanding disease, and to developing new therapeutics and new
materials.
Combinatorial experiments provide new ways to probe the determinants of
protein folding and to identify novel folding sequences. Tens of
millions of sequences may be screened for desired activity. These
techniques are complicated, however, by both the conformational
complexity
of proteins and by the exponentially large numbers of possible
sequences.
Dr. Saven will discuss recent computational methods for identifying the
properties of amino acid sequences likely to fold to a given
three-dimensional
structure.
Directions
to Kutztown University
South Dining Hall is located on the campus. If you are coming
on Rt. 222 from the east, get off at the Kutztown exit onto Main
Street.
You will go through four stoplights. At the fifth stoplight,
which
is at the top of the hill and the entrance onto the campus, make a left
onto Normal Avenue. At the first stop sign take a right onto
Baldy
St. At the first intersection, turn right onto South Campus
Drive.
Drive by the Field house and turn left onto Court Lane. There
should
be plenty of parking in the lot. If you are coming on Rt. 222
from
the west, get off at the Kutztown exit that is about a mile past
Moselem
Springs. At the second stop light, turn right onto Normal Avenue
and follow the directions from above.
Campus
Map
Thursday, September 12, East Stroudsburg University
Reception: 6:00 pm Lower
Dansbury (Dansbury Commons)
Dinner: 6:30 pm Lower
Dansbury (Dansbury Commons)
Meeting, Talk: 7:30
in Moore
Biology Kurz Lecture Hall
Cost:
$23, Students $12
Menu: Salad
- Mixed Baby Field Greens with Balsamic Vinaigrette
Entree - Chicken Piccata, Lemon Capers and
Chablis
Wine, Spinach Orzo, Baby Carrots
OR - Saffron Risotto baked with
Asiago
Cheese, Baby Spinach, Sun-dried Tomatoes and Summer Squash, Drizzled
with
Pesto
Desert - Cappuccino Hazelnut Torte
Meeting: 7:30
in Moore Biology Kurtz Lecture Hall
Contact: Kathy Curnoles
(kcurnoles@esu.edu
or 570-422-3514) by Monday, Sept. 9, 4:00 PM. Please include your name,
affiliation and phone number.
Speaker: Dr.
William Cherry, M.D., Ph.D. Anesthesiologist, Pocono Medical
Center
Bill Cherry is an anesthesiologist
at Pocono Medical Center and will soon be joining the staff at St.
Luke's.
He completed his Residency in Anesthesia at Duke University in 1992,
and
his Internship in Pediatrics at Emory University. He attended
medical
school at the University of Miami. Before his career in medicine,
Bill was a Professor of Chemistry at Louisiana State University in
Baton
Rouge. He completed a post doctoral position in Laser
Photochemistry
at Columbia University, and a Ph.D. in Chemical Quantum Mechanics at
the
University of Washington, Seattle in 1976. He served as a Chevron
Graduate Fellow and a Visiting Scholar at The Australian National
University
and Brookhaven National Laboratories. He has written one book and
authored
46 articles.
Title:
History and Medical Implications of Chemical/Biological Warfare
The history of both chemical
and biological warfare will be discussed. The various agents in use and
their mechanism of action will be examined. Finally, medical and
public health issues will be highlighted.
Directions
to East Stroudsburg University (Its closer than you think!)
Campus
Map
Parking - Parking can be difficult on the ESU campus. Free
parking
is available behind Moore
Hall, and behind Reibman
Administration Building; ample parking should be available after
5:00.
Metered city parking is available along Normal Street. The university
circle
is faculty parking only and is patrolled 24 hours a day. Please
do
not park on the grass.
2001-2002 Meeting Schedule
Reception: 6:00 pm in Harmon
Hall
Dinner: 6:30 pm in Haromon Hall
Meeting, Talk: 7:30
in Miller 33
Cost: $21,
Students and Spouses $11
Menu:
Entree - Chicken Picatta
or Vegtable Pasta
Contact: Diane Molchany (dkmolcha@cedarcrest.edu
or 610-606-4611) by Friday, April 26. Please include your name,
affiliation
and phone number.
Speaker: Dr.
Paul Sherblom, Cedar Crest College
Ttile: Environmental
Persistence of Malathion and it's co-products.
Abstract: Malathion,
an organo-phosphorous insecticide is widely used in domestic, municipal
and agricultural applications. Storm events following application
to lawns, or in agricultural settings, as well as its use in mosquito
control
may lead to malathion entering surface waters. Additionally, its
use in situations such as exotic pest infestations (the Mediterranean
Fruit
Fly and the West Nile Virus) have lead to aerial spray programs with
the
potential exposure of significant portions of the population.
Trace
impurities which may be present in technical grade malathion can
significantly
increase its toxicity to non-target species, including humans.
Results
from two studies concerning the environmental persistence of malathion
and its co-products will be presented and their environmental and human
health implications discussed.
Directions
to Cedar Crest College (with street map)
Campus
Map
Reception: 5:30 pm in Faculty
Dining
Hall - Marquis Hall
Dinner: 6:00 pm in Faculty Dining
Hall - Marquis Hall
Meeting, Talk: 7:30 pm in Jacqua
Auditorium (Room 103) Hugel Science Center
Cost: $20, students $10 (award
recipients will be free)
Menu:
Appetizers - Spanakopita and Chicken Cordon Blue BallsContact: Debbie Bastinelli (bastined@lafayette.edu or 610-330-5213) by noon on Friday, April 5. Please include your name, affiliation and phone number.
Entree - New York Strip Steak, Hazelnut Crusted Salmon or Vegetable Lasagna
Dessert - Marble Cheese Cake
Program: The topics will be Employment Opportunities (by Paul Bouis) and Varieties of Chemical History (by David Brock). This meeting is the annual student awards night.
Abstract:
Varieties of Chemical History The Chemical Heritage Foundation (CHF) seeks to advance the heritage of the chemical and molecular sciences by operating an historical research library; discovering and disseminating information about historical resources; encouraging research, scholarship, and popular writing; publishing historical materials; conducting oral histories; creating exhibits; and taking other appropriate steps to make known the achievements of chemical and molecular scientists and engineers and of related sciences, technologies, and industries. The foundation engages in a wide range of educational activities. This talk will discuss the broad sweep of the history of chemistry, and present example of ways in which we preserve theAuthor:
powerful stories that comprise this history.
David Brock is an historian and program manager with the Beckman Center for the History of Chemistry at the Chemical Heritage Foundation. He received his training in the history and sociology of science at Brown University, the University of Edinburgh, and Princeton University. His area of specialization is in the history of instrumentation. His most recent project was as lead researcher for CHF's publication "Arnold O. Beckman:Directions to Lafayette College (with street map)
One Hundred Years of Excellence."
Reception and dinner in the Bishop McShea College Center - Board room and Faculty Dining Room
Meeting and talk in the Priscilla Payne Hurd Science Center*
Speaker: Dr. James Ferris
Talk Title: The Scanning Probe Microscope as a Proximal Probe of Structure and Properties of
Chemically Modified Surfaces
Reception: 5:15
Dinner: 6:15
Menu: Buffet - Flounder stuffed with Spinach and cheese, Roast Beef, Pasta, Potatoes, Green Beans, Carrots, Chocolate Mousse Cake - Cost $17.75; Students $8.00
Contact: Mrs Renee Fair by 4 PM, Tues. March 12. Renee.Fair@desales.edu or 610-2821100 ext. 1386
Please include your name, affiliation and phone number in case of inclement weather.* Due to limited parking at the Science Center a shuttle bus will be provided from the Bishop McShea College Center
Directions to DeSales
DeSales Campus Map
Reception and dinner in the UBC room of the Haupert Union Building.
Meeting and talk in the Dana Lecture Hall of Science
Speaker: Bill Suits, President of Chromatography Connections.
Talk Title: Identifying Diabolic Pathogens with Separation Techniques
Reception: 5:30
Dinner: 6:30
Contact: LouAnn Vlahovic by noon, Thursday, Feb. 7. melnv01@moravian.edu or 610-861-1300
Please include your name, affiliation and phone number in case of inclement weather.
Directions to Moravian College
Campus Map